BNUB0731
AMACR / p504S(Rabbit polyclonal antibody), 0.2mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNUB0731
- Zusätzliche Namen:
- Alpha-methylacyl-CoA Racemase; AMACR; p504S; CBAS4; RACE
- Anwendung:
- WB, IHC-P
- Konzentration:
- 0.2 mg/ml
- Molekulargewicht:
- 54 kda
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Rabbit
- Reaktivitäten:
- Bovine, Human, Rabbit
- Buffer:
- PBS, 0.05% BSA, 0.05% azide|PBS, 0.05% BSA, 0.05% sodium azide
- Immunogen:
- A synthetic peptide from human AMACR protein
- Formulierung:
- PBS, 0.05% BSA, 0.05% azide
- Klon:
- PAb
- Uniprot:
- Q9UHK6
- Synonyme:
- 2-methylacyl-CoA racemase;alpha-methylacyl-CoA racemase;AMACRD;arginine demethylase and lysine hydroxylase;bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;CBAS4;histone arginine demethylase JMJD6;jmjC domain-containing protein 6;jumonji domain-containing protein 6;lysyl-hydroxylase JMJD6;P504S;peptide-lysine 5-dioxygenase JMJD6;phosphatidylserine receptor;PTDSR;RACE;RM
- Weitere Details:
- This antibody recognizes a protein of 42 kDa, which is identified as Alpha-methylacyl-CoA Racemase (AMACR), also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and overexpressed in prostate carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient