BNCB2012
CD137, Mouse(LOB12), Biotin conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNCB2012
- Zusätzliche Namen:
- 4-1BB ligand receptor; 4-1BB; Mouse; homolog; CD137; HLDA VI; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of Mouse Ly63; Ly63; Mouse; Receptor protein 4 1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)
- Anwendung:
- ELISA, FuncS
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 39 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Rat
- Reaktivitäten:
- Bovine, Mouse, Rat
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Murine CD137 human Fc fusion protein
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- LOB12
- Uniprot:
- P20334
- Synonyme:
- 4-1BB;4-1BB ligand receptor;A930040I11Rik;AA408498;AI325004;Cd137;CD137 antigen;CDw137;GA_x6K02T2PBJ9-7786441-7785503;ILA;Ly6;Ly63;MOR40;MOR40-8P;olfactory receptor 684;olfactory receptor GA_x6K02T2PBJ9-7786441-7785503;secreted CD137 antigen;T-cell antigen 4-1BB;tumor necrosis factor receptor superfamily member 9
- Weitere Details:
- CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12. 3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivo when administered in combination with immune checkpoint inhibitors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient