Cytochrome C(CTC05), Biotin conjugate, 0.1mg/mL

Eine Lieferung in diese Region ist nicht möglich.

SKU:: BNCB0887
Zusätzliche Namen:: CYC; CYCS; HCS; THC4
Anwendung:: Flow Cytometry, WB, IHC-P, IF
Konzentration:: 0.1 mg/ml
Molekulargewicht:: 15 kDa
Quelle:: Animal
Lagerbedingungen:: 2-8[o]C, RT
Hersteller:: Biotium
Host:: Mouse
Reaktivitäten:: Bovine, Canine, Human, Mouse, Rat, Equine, Insect/Arthropod
Buffer:: 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
Immunogen:: Recombinant cytochrome c protein
Formulierung:: PBS, 0.1% BSA, 0.05% azide
Klon:: CTC05
Uniprot:: P99999
Synonyme:: CYC;cytochrome c;HCS;THC4
Weitere Details:: Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Versandbedingungen:: Ambient