BNCB0680
Cyclin B1(V92.1), Biotin conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNCB0680
- Zusätzliche Namen:
- CCNB, CCNB1, CCNB1_HUMAN, G2 Mitotic Specific Cyclin B1
- Anwendung:
- Flow Cytometry, IF
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 55-62 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Hamster, Human, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Hamster Cyclin B1 protein
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- V92.1
- Uniprot:
- P14635
- Synonyme:
- (2-5')oligo(A) synthase 1A;2-5-oligoadenylate synthetase 1A ((2-5)oligo(A) synthetase 1A) (2-5A synthetase 1A) (p42 OAS);2-5A synthase 1A;2'-5' oligoadenylate synthetase 1A;2'-5' oligoadenylate synthetase 1G;2'-5'-oligoadenylate synthase 1A;AI449562;CCNB;G2/mitotic-specific cyclin-B1;L;L2;Mmu-;Mmu-L;Mmu-L2;O;Oas1b;Oi;Oias-1;Oias1;p42 OAS
- Weitere Details:
- This antibody recognizes a protein of 55-62 kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient