BNC882843
SIGLEC1 / CD169 / Sialoadhesin(HSn 7D2), CF488A conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNC882843
- Zusätzliche Namen:
- CD169; CD169 antigen; Sialic acid binding immunoglobulin like lectin 1; Sialic acid-binding Ig-like lectin 1; Sialoadhesin; Siglec-1; SN
- Anwendung:
- Flow Cytometry, WB, IHC-P, FuncS
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 185 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- HSn 7D2
- Synonyme:
- CD169;CG12058;CG12124;CG12124-PA;CG12124-PB;Dmel_CG12058;Dmel_CG12124;Dmel\CG12124;dNPAT;l(1)mbn;lethal(1)malignant blood neoplasm;MPM-2;MPM2;multi sex combs;MXC;mxc-PA;mxc-PB;NPAT;sialic acid binding Ig-like lectin 1, sialoadhesin;sialic acid-binding immunoglobulin-like lectin 1;sialoadhesin;SIGLEC-1;SN
- Weitere Details:
- Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1, 709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient