BNC881176
EMI1(EMI1/1176), CF488A conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNC881176
- Zusätzliche Namen:
- Early Mitotic Inhibitor-1 (EMI1); FBX5; Fbxo31
- Anwendung:
- WB, IHC-P
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 56 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Recombinant fragment (203 amino acid residues between aa 1-250) of human EMI1 protein
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- EMI1/1176
- Uniprot:
- Q9UKT4
- Synonyme:
- early mitotic inhibitor 1;EMI1;F-box only protein 5;F-box protein Fbx5;FBX5;Fbxo31
- Weitere Details:
- This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient