BNC880976
GITR / Tnfrsf18 (Mouse)(DTA-1), CF488A conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNC880976
- Zusätzliche Namen:
- Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18
- Anwendung:
- Flow Cytometry, FuncS
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 66-70 kDa (Homodimer)
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Rat
- Reaktivitäten:
- Bovine, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Mouse CD25 CD4 T cells
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- DTA-1
- Uniprot:
- O35714
- Synonyme:
- AITR;Gi;Gitr;glucocorticoid-induced TNFR-related protein;TBX5;tumor necrosis factor receptor superfamily member 18
- Weitere Details:
- GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
- Versandbedingungen:
- Ambient