BNC880166
CD33(WM53), CF488A conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNC880166
- Zusätzliche Namen:
- gp67; My9; Myeloid cell surface antigen CD33; p67; Sialic acid-binding Ig-like lectin 3 (SIGLEC3)
- Anwendung:
- Flow Cytometry, IHC-P
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 67 kda
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Human AML cells
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- WM53
- Uniprot:
- P20138
- Synonyme:
- BK channel;BKCa;BKCA alpha;calcium-activated potassium channel alpha subunit;calcium-activated potassium channel subunit alpha-1;calcium-activated potassium channel, subfamily M subunit alpha-1;cbv1;CD33 antigen (gp67);CD33 molecule transcript;gp67;k(VCA)alpha;KCa1.1;Kcnma;KCNMA1b;KCNMA1c;maxi K channel;maxiK;myeloid cell surface antigen CD33;p67;potassium channel, calcium activated large conductance subfamily M alpha, member 1;potassium large conductance calcium-activated channel, subfamily M, alpha member 1;sialic acid-binding Ig-like lectin 3;SIGLEC-3;SIGLEC3;Slo;slo homolog;slo-alpha;slo1;slowpoke homolog
- Weitere Details:
- Recognizes a 67 kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient