BNC042321
Calcineurin B / PPP3R1(BE2.1), CF405S conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNC042321
- Zusätzliche Namen:
- Calcineurin B; Calcineurin subunit B type 1; Protein Phosphatase 3 Regulatory Subunit B Alpha; CALNB1; Cna2; CNB; CNB1; PPP3R1
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 19 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Recombinant full-length human Calcineurin B protein
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- BE2.1
- Uniprot:
- P63098
- Synonyme:
- calcineurin B, type I (19kDa);calcineurin subunit B type 1;CALNB1;CNB;CNB1;protein phosphatase 2B regulatory subunit 1;protein phosphatase 2B regulatory subunit B alpha;Protein phosphatase 3 regulatory subunit B alpha isoform 1
- Weitere Details:
- This antibody recognizes the Calcineurin B alpha protein, encoded by the PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B Alpha) gene. Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient