BNC041258
TDP2 / EAPII (TDP2/1258), CF405S conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNC041258
- Zusätzliche Namen:
- 5'-Tyr-DNA phosphodiesterase; EAP2; EAPII; ETS1-associated protein 2; ETS1-associated protein II; TRAF and TNF receptor-associated protein; TTRAP; Tyr-DNA phosphodiesterase 2; Tyrosyl-DNA phosphodiesterase 2 (TDP2)
- Anwendung:
- IHC-P
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- ~41 kDa
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- Recombinant human full-length TDP2 protein
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- TDP2/1258
- Uniprot:
- O95551
- Synonyme:
- 5'-Tyr-DNA phosphodiesterase;5'-tyrosyl-DNA phosphodiesterase;AD022;dJ30M3.3;EAP2;EAPII;epididymis secretory sperm binding protein;ETS1-associated protein 2;ETS1-associated protein II;hTDP2;TRAF and TNF receptor-associated protein;TTRAP;tyr-DNA phosphodiesterase 2;tyrosyl-DNA phosphodiesterase 2;tyrosyl-RNA phosphodiesterase;VPg unlinkase
- Weitere Details:
- This MAb recognizes a protein of 41 kDa, which is identified as TDP2. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient