BNC040202
Clostridium difficile (Toxin A)(253/422), CF405S conjugate, 0.1mg/mL
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- BNC040202
- Zusätzliche Namen:
- Clostridium difficile; C. difficile; tcdA; toxA
- Konzentration:
- 0.1 mg/ml
- Molekulargewicht:
- 308 kDa (Toxin A)
- Quelle:
- Animal
- Lagerbedingungen:
- 2-8[o]C, RT
- Hersteller:
- Biotium
- Host:
- Mouse
- Reaktivitäten:
- Bacteria, Bovine, Mouse
- Buffer:
- 0.05% sodium azide|PBS, 0.1% BSA, 0.05% azide
- Immunogen:
- C. difficile Toxin A
- Formulierung:
- PBS, 0.1% BSA, 0.05% azide
- Klon:
- 253/422
- Uniprot:
- P16154
- Weitere Details:
- This MAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Versandbedingungen:
- Ambient