YHA41901
Recombinant Human NPC1 Protein, N-His
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£168.00
- SKU:
- YHA41901
- Zusätzliche Namen:
- NPCintracellularcholesteroltransporter1,Niemann-PickC1protein,NPC1,receptorforebolavirus,receptorforebolavirus
- Anwendung:
- ELISA, SDS-PAGE, WB
- Physischer Zustand:
- Lyophilized
- Molekulargewicht:
- 29.31kDa
- Reinheit:
- >90% as determined by sds-page.
- Lagerbedingungen:
- -70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Hersteller:
- AntibodySystems
- Buffer:
- LyophilizedfromasolutioninPBSpH7.4,0.02%NLS,1mMEDTA,4%Trehalose,1%Mannitol.
- Spezies:
- Human
- Uniprot:
- O15118
- Synonyme:
- Niemann-Pick C1 protein;NPC;NPC intracellular cholesterol transporter 1;POGZ;SLC65A1;truncated Niemann-Pick C1
- Weitere Details:
- NPC1/Niemann-PickC1protein(Microbialinfection)Actsasanendosomalentryreceptorforebolavirus. IntracellularcholesteroltransporterwhichactsinconcertwithNPC2andplaysanimportantroleintheegressofcholesterolfromtheendosomal/lysosomalcompartment.UnesterifiedcholesterolthathasbeenreleasedfromLDLsinthelumenofthelateendosomes/lysosomesistransferredbyNPC2tothecholesterol-bindingpocketintheN-terminaldomainofNPC1.CholesterolbindstoNPC1withthehydroxylgroupburiedinthebindingpocket.Bindsoxysterolwithhigheraffinitythancholesterol.Mayplayaroleinvesiculartraffickinginglia,aprocessthatmaybecrucialformaintainingthestructuralandfunctionalintegrityofnerveterminals(Probable).
- Versandbedingungen:
- Dry Ice