30-1313PC-Cy5.5
PerCP-Cy5.5 Conjugated Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-229)
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£741.00
- SKU:
- 30-1313PC-Cy5.5
- Zusätzliche Namen:
- ENG||END||Endoglin||HHT1||ORW1
- Aufreinigung:
- Purified antibody is conjugated with activated tandem dye of activated Peridinin-Chlorophyll Protein-Cyanine 5.5 (PerCP-Cy5.5) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Lagerbedingungen:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Hersteller:
- Abeomics Inc.
- Host:
- Mouse
- Reaktivitäten:
- Human
- Immunogen:
- Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
- Klon:
- MEM-229
- Weitere Details:
- CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing; infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. Specificity: The antibody MEM-229 recognizes an extracellular epitope of CD105 (Endoglin); a 90 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels); activated monocytes and tissue macrophages; stromal cells of certain tissues including bone marrow; pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
- Versandbedingungen:
- Blue Ice