Anti-CD7 Monoclonal Antibody (Clone:MEM-186) PerCP-Cy5.5

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£741.00

SKU:: 30-1112PC-Cy5.5
Zusätzliche Namen:: CD7
Aufreinigung:: Purified by protein-A affinity chromatography
Lagerbedingungen:: Store at 2-8[o]C. Do not freeze.
Hersteller:: Abeomics Inc.
Host:: Mouse
Reaktivitäten:: Human
Immunogen:: Human acute myelogenous leukaemia cell line KG-1.
Klon:: MEM-186
Weitere Details:: CD7; also known as gp40; is a member of the immunoglobulin superfamily found on T cells; NK cells; thymocytes; hematopoietic progenitors; and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes; presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7; epithelial cell secreted protein K12; is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.