Polyclonal Antibody to CADM1

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£319.00

SKU:: 11-4037
Zusätzliche Namen:: CADM1||IGSF4||IGSF4A||NECL2||SYNCAM||TSLC1
Aufreinigung:: Protein A Chromatography
Hersteller:: Abeomics Inc.
Host:: Rabbit
Reaktivitäten:: Human
Uniprot:: Q9BY67
Gendetails:: CADM1
Weitere Details:: Cell Adhesion Molecule 1 (CADM1) encodes a multifunctional immunoglobulin-like cell adhesion molecule whose cytoplasmic domain contains a type II PSD95/Dlg/ZO-1 (PDZ)-binding motif (BM) for associating with other intracellular proteins. CADM1 lacks expression in T lymphocytes of healthy individuals and is overexpressed in adult T-cell leukemia-lymphoma (ATL) cells. CADM1 generates a membrane-associated C-terminal fragment, AlphaCTF, through A disintegrin- and metalloprotease-10-mediated ectodomain shedding, subsequently releasing the intracellular domain (ICD) through gamma-secretase-mediated intramembrane shedding of alphaCTF. alphaCTF localizes to mitochondria and induces apoptosis in lung epithelial cells. In women with multiple cervical biopsies, CADM1/MAL methylation increases with severity of the lesion and is lesion-specific. CADM1/MAL methylation status in cervical scrapes appears to be representative of the worst underlying lesion, particularly for CIN3 and cervical cancer.