Polyclonal Antibody to DUBA

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£319.00

SKU:: 11-3014
Zusätzliche Namen:: OTUD5
Aufreinigung:: Protein A Chromatography
Hersteller:: Abeomics Inc.
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Uniprot:: Q96G74
Gendetails:: OTUD5
Weitere Details:: DUBA belongs to a subfamily of 14 DUBs characterized by an OTU (Ovarian Tumor) domain. This protein suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. DUBA forms a direct complex with p53 and controls level of ubiquitination. The function of DUBA is required to allow the rapid activation of p53-dependent transcription and a p53-dependent apoptosis in response to DNA damage stress.