10-7648
Monoclonal Antibody to Mouse PD-L1 (Clone: 10F.9G2)
Größe
£319.00
- SKU:
- 10-7648
- Zusätzliche Namen:
- Programmed cell death 1 ligand 1, Programmed cell death 1 ligand 1, Programmed death ligand 1, B7-H1
- Aufreinigung:
- Protein G Chromatography
- Hersteller:
- Abeomics Inc.
- Host:
- Rat
- Reaktivitäten:
- Mouse
- Klon:
- 10F.9G2
- Uniprot:
- Q9EP73
- Gendetails:
- Cd274
- Weitere Details:
- PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274/PD-L1 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
- Versandbedingungen:
- Blue Ice