Monoclonal Antibody to Mouse PD-1 (Clone: ABM5F42)

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£319.00

SKU:: 10-7612
Zusätzliche Namen:: Programmed cell death protein 1, Protein PD-1, CD279
Aufreinigung:: Protein G Chromatography
Hersteller:: Abeomics Inc.
Host:: Rat
Reaktivitäten:: Mouse
Klon:: ABM5F42
Uniprot:: Q02242
Gendetails:: Pdcd1
Weitere Details:: PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.