10-7599
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Größe
£319.00
- SKU:
- 10-7599
- Zusätzliche Namen:
- CD274||B7H1||PDCD1L1||PDCD1LG1||PDL1
- Aufreinigung:
- Protein G Chromatography
- Hersteller:
- Abeomics Inc.
- Host:
- Mouse
- Reaktivitäten:
- Human
- Klon:
- ABM5F25
- Uniprot:
- Q9NZQ7
- Gendetails:
- CD274
- Weitere Details:
- PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitates apoptosis of activated T cells, and induces T cell anergy. Aberrant expression and dysregulation of CD274 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.
- Versandbedingungen:
- Blue Ice