Recombinant Human IgD Protein

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£276.00

SKU:: RPT0021
Zusätzliche Namen:: IGHD, IgD ,Ig delta chain C region,Ig delta chain C region NIG-65,Ig delta chain C region WAH ,Immunoglobulin heavy constant delta
Molekulargewicht:: 45-60 kDa
Reinheit:: 85%
Lagerbedingungen:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Immunogen:: Arg99-Lys384
Formulierung:: Recombinant Human IgD Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg99-Lys384) of Human IgD (Accession #P01880-1) fused with a His tag at the C-terminus.
Spezies:: Human
Sequenz:: WPESPKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPECPSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGLLERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSLNLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPRSTTFWAWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK
Uniprot:: P01880-1
Synonyme:: constant region of heavy chain of IgD;Ig delta chain C region;Ig delta chain C region NIG-65;Ig delta chain C region WAH
Weitere Details:: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Versandbedingungen:: Blue Ice