RP03556
Recombinant Human SerpinB2 Protein
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£645.00
- SKU:
- RP03556
- Zusätzliche Namen:
- SERPINB2, PAI2, PLANH2,Plasminogen activator inhibitor 2,PAI-2,Serpin B2, Urokinase inhibitor
- Molekulargewicht:
- 55-70 kDa
- Reinheit:
- ≥90%
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Immunogen:
- Met 1-Pro 415
- Formulierung:
- Recombinant Human SerpinB2 Protein is produced by Baculovirus-Insect Cells system. The target protein is expressed with sequence (Met 1-Pro 415) of Human SerpinB2(Accession #NP_002566.1) fused with the GST tag at the N-terminus.
- Spezies:
- Human
- Uniprot:
- P05120
- Synonyme:
- HsT1201;monocyte Arg-serpin;PAI;PAI-2;PAI2;placental plasminogen activator inhibitor;PLANH2;plasminogen activator inhibitor 2;plasminogen activator inhibitor, type II (arginine-serpin);plasminogen-activator inhibitor;serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2;serpin B2;serpin peptidase inhibitor, clade B (ovalbumin), member 2;urokinase inhibitor
- Weitere Details:
- Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB2 is a major product of activated monocytes and macrophages and is substantially induced during most inflammatory processes. Distinct from its widely described extracellular role as an inhibitor of urokinase plasminogen activator. SerpinB2 has been shown to have an intracellular role as a retinoblastoma protein (Rb)-binding protein that inhibits Rb degradation. SerpinB2 is widely described as an inhibitor of urokinase plasminogen activator. SerpinB2 inhibits urokinase-type plasminogen activator. The monocyte derived SerpinB2 is distinct from the endothelial cell-derived PAI-1. SerpinB2 is a potentially important inducible host factor that significantly promotes HIV-1 replication.
- Versandbedingungen:
- Blue Ice