Recombinant Mouse FLT-3/FLK-2/CD135 Protein

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£133.00

SKU:: RP02957
Zusätzliche Namen:: CD135|FLK-2|FLK2|FLT3|STK1
Molekulargewicht:: 120-140 kDa
Reinheit:: ≥95%
Lagerbedingungen:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Immunogen:: Met1-Ser544
Formulierung:: Recombinant Mouse FLT-3/FLK-2/CD135 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ser544) of mouse FLT-3/FLK-2 (Accession #NP_034359.2) fused with a hFc tag at the C-terminus.
Spezies:: Mouse
Sequenz:: MRALAQRSDRRLLLLVVLSVMILETVTNQDLPVIKCVLISHENNGSSAGKPSSYRMVRGSPEDLQCTPRRQSEGTVYEAATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQAGEYLLHIQSEAANYTVLFTVNVRDTQLYVLRRPYFRKMENQDALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRKEEKVLHELFGTDIRCCARNALGRESTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMFTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQDNIS
Uniprot:: Q00342
Synonyme:: B230315G04;CD135;fetal liver kinase 2;FL cytokine receptor;Flk;Flk-;Flk-2;Flk2;Flt-;Flt-3;Fms-like tyrosine kinase 3;Ly72;receptor-type tyrosine-protein kinase FLT3;tyrosine-protein kinase FLT3;tyrosine-protein kinase receptor flk-2;wmf;wmfl
Weitere Details:: This protein is a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Versandbedingungen:: Blue Ice