RP02731
Recombinant Human Annexin A2/ANXA2 Protein
Größe
£133.00
- SKU:
- RP02731
- Zusätzliche Namen:
- Annexin A2|Annexin II|ANX2|ANX2L4|ANXA2|CAL1H|Chromobindin-8|LIP2PAP-IV|Lipocortin II|LPC2D|LPC2DP36|p36|PAP-IV
- Molekulargewicht:
- 39 kDa
- Reinheit:
- ≥95%
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Immunogen:
- Ser2-Asp339
- Formulierung:
- Recombinant Human Annexin A2/ANXA2 Protein is produced by E. coli expression system. The target protein is expressed with sequence Ser2-Asp339. of Human Annexin A2/ANXA2 (Accession #) fused with His tag at the N-terminal
- Spezies:
- Human
- Uniprot:
- P07355
- Synonyme:
- annexin A2;annexin II;annexin-2;ANX2;ANX2L4;CAL1H;calpactin I heavy chain;calpactin I heavy polypeptide;calpactin-1 heavy chain;chromobindin 8;Chromobindin-8;epididymis secretory protein Li 270;epididymis secretory sperm binding protein;HEL-S-270;LIP2;lipocortin II;LPC2;LPC2D;P36;PAP-IV;placental anticoagulant protein IV;protein I
- Weitere Details:
- ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
- Versandbedingungen:
- Blue Ice