Recombinant Human IL-31 Protein

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£145.00

SKU:: RP01757
Zusätzliche Namen:: IL-31|IL31
Molekulargewicht:: 25-35 kDa
Reinheit:: ≥90%
Lagerbedingungen:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Immunogen:: Ser24-Thr164
Formulierung:: Recombinant Human IL-31 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Thr164) of human IL-31 (Accession #NP_001014358.1) fused with a 6xHis tag at the N-terminus.
Spezies:: Human
Sequenz:: SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
Uniprot:: Q6EBC2
Synonyme:: IL-31;interleukin-31
Weitere Details:: IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor B Beta (OSMRB Beta) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.