RP01342
Recombinant Human IFNAR2 Protein
Größe
£133.00
- SKU:
- RP01342
- Zusätzliche Namen:
- IFNAR2, IFN-R, IFN-alpha-REC, IFNABR, IFNARB, IMD45, interferon alpha/beta receptor 2,IFN-R,IFN-alpha-REC,IFNABR,IFNARB,IMD45
- Molekulargewicht:
- Approximately 70 kDa
- Reinheit:
- ≥95%
- Lagerbedingungen:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Immunogen:
- Ile27-Lys243
- Formulierung:
- Recombinant Human IFNAR2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile27-Lys243) of human IFNAR2/IFNARB (Accession #NP_997468.1) fused with Fc, 6xHis tag at the C-terminus.
- Spezies:
- Human
- Sequenz:
- ISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAK
- Uniprot:
- P48551-1
- Synonyme:
- human interferon alpha/beta receptor;IFN-alpha-REC;IFN-alpha/beta receptor 2;IFN-R;IFN-R-2;IFNABR;IFNalpha/beta receptor subunit 2;IFNARB;IMD45;interferon (alpha, beta and omega) receptor 2;interferon alpha binding protein;interferon alpha/beta receptor 2;interferon receptor;interferon-alpha/beta receptor beta chain;type I interferon receptor 2
- Weitere Details:
- Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family.Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNA Alpha therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNA Alpha therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNA Alpha2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNB Beta, it recycles back to the cell surface.
- Versandbedingungen:
- Blue Ice