Recombinant Mouse CSF-1/M-CSF Protein (With Carrier)

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£193.00

SKU:: RP01216SC
Zusätzliche Namen:: Csf1, Csfm, Macrophage colony-stimulating factor 1, CSF-1, MCSF,Processed macrophage colony-stimulating factor 1
Molekulargewicht:: 20-25 kDa
Reinheit:: ≥95%
Lagerbedingungen:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Immunogen:: Met1-Pro187
Formulierung:: Recombinant Mouse CSF-1/M-CSF Protein (With Carrier) is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Pro187) of Mouse CSF-1/M-CSF (Accession #NP_031804.3.) fused with No tag.
Spezies:: Mouse
Uniprot:: P07141-1
Synonyme:: C87615;Csf;CSF-;Csfm;M-CS;macrophage colony-stimulating factor 1;MCSF;op;osteopetrosis
Weitere Details:: Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

Versandbedingungen:: Blue Ice