Recombinant Human FGFR-3 alpha (IIIb)/CD333 Protein

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£353.00

SKU:: RP00463
Zusätzliche Namen:: ACH|CD333|CEK|CEK2|EC 2.7.10|FGF R3|FGFR3|HSFGFR3EX|JTK4
Molekulargewicht:: 65-75 kDa
Reinheit:: ≥ 95 % as determined by SDS-PAGE;≥ 95 %
Lagerbedingungen:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Immunogen:: Glu23-Gly377
Formulierung:: Recombinant Human FGFR-3 alpha (IIIb)/CD333 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu23-Gly377) of Human FGFR3 alpha (IIIb) (Accession #P22607-2) fused with a C-His&Avi tag at the C-terminus.
Spezies:: Human
Sequenz:: ESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAG
Uniprot:: P22607-2
Synonyme:: ACH;CD333;CEK2;FGFR-3;fibroblast growth factor receptor 3;fibroblast growth factor receptor 3 variant 4;fibroblast growth factor receptor 3-S;HSFGFR3EX;hydroxyaryl-protein kinase;JTK4;tyrosine kinase JTK4
Weitere Details:: Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid?box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.

Versandbedingungen:: Blue Ice