Rabbit anti-Human Thrombopoietin/Tpo monoclonal antibody

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£372.30

War £438.00

SKU:: RMK0589
Zusätzliche Namen:: MGDF|MKCSF|ML|MPLLG|THCYT1|TPO
Anwendung:: ELISA
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Abclonal
Reaktivitäten:: Human
Immunogen:: Recombinant Human Thrombopoietin/Tpo protein
Formulierung:: Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.3.
Spezies:: Human
Uniprot:: P40225
Synonyme:: c-mpl ligand;megakaryocyte colony-stimulating factor;megakaryocyte growth and development factor;megakaryocyte stimulating factor;MGDF;MKCSF;ML;MPL ligand;MPLLG;myeloproliferative leukemia virus oncogene ligand;prepro-thrombopoietin;THCYT1;thrombopoietin;TPO
Weitere Details:: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.