Rabbit Anti-Human IFN-alpha monoclonal antibody

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£372.30

War £438.00

SKU:: RMK0519
Zusätzliche Namen:: IFN-alpha-2|IFN-alphaA|IFNA|IFNA2B|leIF A
Anwendung:: CLIA, ELISA
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Abclonal
Immunogen:: Recombinant Human IFN-alpha protein
Formulierung:: Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
Spezies:: Human
Uniprot:: P01563
Synonyme:: alpha-2a interferon;IFN-alpha-2;IFN-alphaA;IFNA;IFNA2B;interferon alpha 2a;interferon alpha 2b;interferon alpha A;interferon alpha-2;Interferon alpha-A;leIF A
Weitere Details:: This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach.