Rabbit anti-Human IL-13 monoclonal antibody

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£372.30

War £438.00

SKU:: RMK0200
Zusätzliche Namen:: IL-13|P600
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Abclonal
Immunogen:: Recombinant Human IL-13 Protein
Formulierung:: Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
Spezies:: Human
Uniprot:: P35225
Synonyme:: IL-13;interleukin-13;P600
Weitere Details:: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.