Rabbit anti-Human CD177 monoclonal antibody

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£347.65

War £409.00

SKU:: RMK0016
Zusätzliche Namen:: HNA-2a|HNA2A|NB1|NB1 GP|PRV-1|PRV1
Anwendung:: ELISA
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Abclonal
Immunogen:: Recombinant human CD177 Protein
Formulierung:: Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.4.
Spezies:: Human
Uniprot:: Q8N6Q3
Synonyme:: CD177 antigen;cell surface receptor;HNA-2a;HNA2A;human neutrophil alloantigen 2a;NB1;NB1 glycoprotein;NB1 GP;polycythemia rubra vera protein 1;PRV-1;PRV1
Weitere Details:: This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.