Rabbit anti-Human PGII monoclonal antibody (CAP)

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£372.30

War £438.00

SKU:: RM17837
Zusätzliche Namen:: PEPC|PGII
Anwendung:: ELISA
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Immunogen:: Recombinant Human PGII
Formulierung:: Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300,PH 7.4.
Uniprot:: P20142
Synonyme:: gastricsin;PEPC;pepsin C;pepsinogen C;pepsinogen group II;PGII;preprogastricsin
Weitere Details:: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.