Rabbit anti-Human IL-10 monoclonal antibody (CAP)

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£347.65

War £409.00

SKU:: RM17643
Zusätzliche Namen:: CSIF|GVHDS|IL-10|IL10A|TGIF
Anwendung:: CLIA
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Abclonal
Immunogen:: Recombinant Human IL-10 Protein Ser19-Asn178 Accession #P22301
Formulierung:: Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
Spezies:: Human
Uniprot:: P22301
Synonyme:: CSIF;cytokine synthesis inhibitory factor;GVHDS;IL-10;IL10A;interleukin-10;T-cell growth inhibitory factor;TGIF
Weitere Details:: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.