Rabbit anti-Human AMH/MIS monoclonal antibody (CAP)

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£372.30

War £438.00

SKU:: RM17623
Zusätzliche Namen:: MIF|MIS
Anwendung:: ELISA
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C
Hersteller:: Abclonal
Immunogen:: Recombinant Human AMH/MIS Protein Leu25-Arg560 Accession #Q6GTN3
Formulierung:: Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.3.
Spezies:: Human
Uniprot:: P03971
Synonyme:: anti-Muellerian hormone;MIF;MIS;muellerian-inhibiting factor;muellerian-inhibiting substance;Mullerian inhibiting factor;Mullerian inhibiting substance
Weitere Details:: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome.