Phospho-TIFA-T9 Rabbit monoclonal antibody

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SKU:: AP1604
Zusätzliche Namen:: Phospho-TIFA-T9|T2BP|T6BP|TIFAA
Anwendung:: ELISA, WB
Molekulargewicht:: 21 kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Uniprot:: Q96CG3
Synonyme:: putative MAPK-activating protein PM14;putative NF-kappa-B-activating protein 20;T2BP;T6BP;TIFAA;TRAF-interacting protein with a forkhead-associated domain;TRAF-interacting protein with FHA domain-containing protein A;TRAF2 binding protein;TRAF2-binding protein;TRAF6 binding protein
Weitere Details:: This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response.