AP1550
Phospho-MLKL-S345 Rabbit monoclonal antibody
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- SKU:
- AP1550
- Zusätzliche Namen:
- 9130019I15Rik
- Anwendung:
- ELISA, WB, IP
- Molekulargewicht:
- 55kDa
- Spezies-Reaktivität:
- Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulierung:
- Phospho S345
- Uniprot:
- Q9D2Y4
- Synonyme:
- 9130019I15Rik;hMLKL;mixed lineage kinase domain-like protein
- Weitere Details:
- This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
- Versandbedingungen:
- Blue Ice