AP1541
Phospho-RB-S807/811 Rabbit monoclonal antibody
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- SKU:
- AP1541
- Zusätzliche Namen:
- OSRC|p105-Rb|p110-RB1|Phospho-RB-S807/811|pp110|PPP1R130|pRb|RB
- Anwendung:
- ELISA, WB, IF, ICC, IP
- Molekulargewicht:
- 110kDa/110KD
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Immunogen:
- Synthetic peptide. This information is considered to be commercially sensitive.
- Formulierung:
- Phospho S807/811
- Sequenz:
- SPLKS
- Uniprot:
- P06400
- Synonyme:
- exon 17 tumor GOS561 substitution mutation causes premature stop;GOS563 exon 17 substitution mutation causes premature stop;OSRC;p105-Rb;p110-RB1;pp110;PPP1R130;pRb;prepro-retinoblastoma-associated protein;protein phosphatase 1, regulatory subunit 130;RB;retinoblastoma 1;retinoblastoma suspectibility protein;retinoblastoma-associated protein
- Weitere Details:
- The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
- Versandbedingungen:
- Blue Ice