RPE65 Rabbit polyclonal antibody

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£151.00

SKU:: A9841
Zusätzliche Namen:: BCO3|LCA2|mRPE65|p63|rd12|RP20|RPE65|sRPE65
Anwendung:: ELISA, WB, IF
Molekulargewicht:: 65kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: NYMDCFESNETMGVWLHIADKKRKKYLNNKYRTSPFNLFHHINTYEDNGFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYCGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS
Uniprot:: Q16518
Synonyme:: all-trans-retinyl-palmitate hydrolase;BCO family, member 3;BCO3;LCA2;lutein isomerase;meso-zeaxanthin isomerase;mRPE65;p63;RBP-binding membrane protein;rd12;retinal pigment epithelium specific protein 65;retinal pigment epithelium-specific 65 kDa protein;retinal pigment epithelium-specific protein 65kDa;retinitis pigmentosa 20 (autosomal recessive);retinoid isomerohydrolase;retinol isomerase;RP20;RPE65, retinoid isomerohydrolase;sRPE65
Weitere Details:: The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital.

Versandbedingungen:: Blue Ice