PHLPP1 Rabbit polyclonal antibody

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£151.00

SKU:: A9542
Zusätzliche Namen:: PHLPP|PHLPP1|PLEKHE1|PPM3A|SCOP
Anwendung:: ELISA, WB, IHC-P, IF, ICC
Molekulargewicht:: 185kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: DQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDS
Uniprot:: O60346
Synonyme:: PH domain leucine-rich repeat-containing protein phosphatase 1;PH domain-containing family E member 1;PHLPP;pleckstrin homology domain containing, family E (with leucine rich repeats) member 1;Pleckstrin homology domain-containing family E member 1;PLEKHE1;PPM3A;protein phosphatase, Mg2+/Mn2+ dependent 3A;SCN circadian oscillatory protein;SCOP;suprachiasmatic nucleus circadian oscillatory protein
Weitere Details:: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

Versandbedingungen:: Blue Ice