A8517
RNF34 Rabbit polyclonal antibody
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£151.00
- SKU:
- A8517
- Zusätzliche Namen:
- CARP-1|CARP1|hRFI|RFI|RIF|RIFF|RNF34
- Anwendung:
- ELISA, WB, IF, ICC
- Molekulargewicht:
- 42kda
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulierung:
- Unmodified
- Sequenz:
- MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSAN
- Uniprot:
- Q969K3
- Synonyme:
- CARP-1;CARP1;caspase regulator CARP1;caspases-8 and -10-associated RING finger protein 1;E3 ubiquitin-protein ligase RNF34;FYVE-RING finger protein MOMO;hRFI;human RING finger homologous to inhibitor of apoptosis protein;RFI;RIF;RIFF;RING finger protein 34;ring finger protein 34, E3 ubiquitin protein ligase;RING finger protein RIFF;RING-type E3 ubiquitin transferase RNF34
- Weitere Details:
- The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.
- Versandbedingungen:
- Blue Ice