A7125
ALS2 Rabbit polyclonal antibody
Größe
£152.00
- SKU:
- A7125
- Zusätzliche Namen:
- ALS2|ALS2CR6|ALSJ|IAHSP|PLSJ
- Anwendung:
- ELISA, WB, IF, ICC
- Molekulargewicht:
- 184kDa
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C 50% glycerol. Avoid freeze/thaw cycles.
- Hersteller:
- Abclonal
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulierung:
- Unmodified
- Sequenz:
- GVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTTP
- Uniprot:
- Q96Q42
- Synonyme:
- ALS2, alsin Rho guanine nucleotide exchange factor;ALS2CR6;alsin;ALSJ;amyotrophic lateral sclerosis 2 (juvenile);amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein;amyotrophic lateral sclerosis 2 protein;IAHSP;PLSJ
- Weitere Details:
- The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
- Versandbedingungen:
- Blue Ice