Rad18 Rabbit monoclonal antibody

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SKU:: A4339
Zusätzliche Namen:: Rad18|RNF73
Anwendung:: ELISA, WB
Molekulargewicht:: 70 kDa/90 kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESP
Uniprot:: Q9NS91
Synonyme:: E3 ubiquitin-protein ligase RAD18;hHR18;hRAD18;postreplication repair protein hRAD18p;postreplication repair protein RAD18;RAD18 homolog;RAD18, S. cerevisiae, homolog;RING finger protein 73;RING-type E3 ubiquitin transferase RAD18;RNF73
Weitere Details:: The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.