PE Rabbit anti-Mouse CXCR5/CD185 monoclonal antibody

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SKU:: A29054
Zusätzliche Namen:: Blr1|CXC-R5|CXCR-5|Gpcr6|MDR15
Anwendung:: Flow Cytometry
Spezies-Reaktivität:: Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Uniprot:: Q04683
Synonyme:: Bl;BLR1;burkitt lymphoma receptor 1 homolog;Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5);Burkitt lymphoma receptor 1, GTP-binding protein;C-X-C chemokine receptor type 5;CD185;chemochine (C-X-C motif) receptor 5;chemokine (C-X-C motif) receptor 5;CXC-R5;CXCR-;CXCR-5;Gpc;Gpcr6;MDR-15;MDR15;monocyte-derived receptor 15
Weitere Details:: CXCR5 is a G protein-coupled receptor belonging to the chemokine receptor subfamily. Once it binds to its ligand (chemokine CXCL13), CXCR5 will activate multiple intracellular signal transduction pathways, thereby regulating cell proliferation, survival and migration. CXCR5 is expressed in mature B cells and follicular helper T cells, and it responds to the CXCL13 gradient, thereby regulating the migration of lymphocytes to secondary lymphoid tissues. CXCR5 is also highly expressed in primary breast cancer cells, which is related to their growth and metastasis tendencies.