ABflo[R] 488 Rat anti-Mouse CD115/CSF-1R monoclonal antibody

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SKU:: A28661
Zusätzliche Namen:: CD115|CSF-1R|Csfmr|Fim-2|Fim2|Fms|M-CSF-R|M-CSFR
Anwendung:: Flow Cytometry
Spezies-Reaktivität:: Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rat
Reaktivitäten:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Uniprot:: P09581
Synonyme:: AI323359;BANDDOS;C-FMS;CD115;CD115 antigen;Csf;CSF-;CSF-1 receptor;CSF-1-R;CSF-1R;Csfmr;CSFR;Fim;Fim-;Fim-2;FIM2;Fm;FMS;FMS proto-oncogene;HDLS;M-CS;M-CSF-R;M-CSFR;macrophage colony stimulating factor I receptor;macrophage colony-stimulating factor 1 receptor;McDonough feline sarcoma viral (v-fms) oncogene homolog;proto-oncogene c-Fms;proto-oncogene fms
Weitere Details:: CSF-1R, also known as CD115 and M-CSFR, is a type I transmembrane protein belonging to the platelet-derived growth factor receptor family. The natural ligands for this c-fms (Fms) proto-oncogene product include M-CSF and IL-34. Structural studies of CD115 have described an immunoglobulin (Ig)-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail. Upon activation, the receptor not only undergoes phosphorylation and ubiquitination of its intracellular residues but also induces homodimerization. CD115 directly influences the differentiation and proliferation of tissue macrophages and osteoclasts. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasma cells, conventional dendritic cells, and osteoclasts.

Versandbedingungen:: Blue Ice