APC Mouse anti-Human CD192/CCR2 monoclonal antibody

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SKU:: A28626
Zusätzliche Namen:: CC-CKR-2|CCR-2|CCR2A|CCR2B|CD192|CKR2|CKR2A|CKR2B|CMKBR2|MCP-1-R
Anwendung:: Flow Cytometry
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Mouse
Reaktivitäten:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Uniprot:: P41597
Synonyme:: C-C chemokine receptor type 2;CC-CKR-2;CCR-2;CCR2A;CCR2B;CD192;chemokine (C-C motif) receptor 2;CKR2;CKR2A;CKR2B;CMKBR2;MCP-1 receptor;MCP-1-R;monocyte chemoattractant protein 1 receptor;monocyte chemotactic protein 1 receptor
Weitere Details:: CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, -2, -3, and -4). Two alternatively spliced variants (CCR2A and CCR2B) were initially described, which differ in their C-terminal cytoplasmic tails. The adhesion of monocytes to arterial endothelium and their subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. Both CCR2 and MCP-1 are implicated in atherosclerotic plaque formation. MCP-1, induced in endothelial cells by modified low-density lipoprotein (LDL), may trigger firm monocyte attachment to the vascular endothelium under flow conditions. Local overexpression of MCP-1 within the vessel wall induces macrophage infiltration and the development of atherosclerotic lesions. Obesity induces a state of chronic inflammation, which is associated with numerous clinically significant complications, including insulin resistance, diabetes mellitus, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 plays a critical role in the development of obesity and the associated inflammation within adipose tissue.

Versandbedingungen:: Blue Ice