PE Rabbit anti-Mouse CD70 monoclonal antibody

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SKU:: A28353
Zusätzliche Namen:: Cd27l|CD27LG|Tnfsf7|Tnlg8a
Anwendung:: Flow Cytometry
Spezies-Reaktivität:: Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: QQQRLLEHPEPHTAELQLNLTVPRKDPTLRWGAGPALGRSFTHGPELEEGHLRIHQDGLYRLHIQVTLANCSSPGSTLQHRATLAVGICSPAAHGISLLRGRFGQDCTVALQRLTYLVHGDVLCTNLTLPLLPSRNADETFFGVQWICP
Uniprot:: O55237
Synonyme:: CD27 ligand;CD27-L;CD27L;CD27LG;CD70 antigen;Ki-24 antigen;LPFS3;surface antigen CD70;Tnfs;TNFSF7;TNLG8A;tumor necrosis factor ligand 8A;tumor necrosis factor ligand superfamily member 7
Weitere Details:: CD70 is a type II transmembrane glycoprotein and a member of the tumor necrosis factor ligand superfamily (TNFSF), also known as CD27L and TNFSF7. It is constitutively expressed on medullary thymic epithelial cells. Its expression can be induced on activated lymphocytes (B cells, T cells, and NK cells) and dendritic cells. CD70 serves as the ligand for CD27, a co-stimulatory receptor that plays a critical role in T cell activation and proliferation. Overexpression of CD70 has been reported in various malignancies, such as renal cell carcinoma, glioblastoma, and non-small cell lung carcinoma, and it is being actively pursued as a therapeutic target.