[KD Validated] PER1 Rabbit monoclonal antibody

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SKU:: A28260
Zusätzliche Namen:: hPER|PER|RIGUI
Anwendung:: ELISA, WB, IF, ICC
Molekulargewicht:: 150 kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: HITSEYTLQNQDTFSVAVSFLTGRIVYISEQAAVLLRCKRDVFRGTRFSELLAPQDVGVFYGSTAPSRL
Uniprot:: O15534
Synonyme:: circadian clock protein PERIOD 1;circadian pacemaker protein RIGUI;hPER;hPER1;PER;period circadian clock 1;period circadian protein homolog 1;period homolog 1;Period, drosophila, homolog of;RIGUI
Weitere Details:: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.