PE Rabbit anti-Mouse CD352/SLAMF6 monoclonal antibody

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SKU:: A27924
Zusätzliche Namen:: KAL1|KAL1b|Ly108|NTB-A|NTBA|SF2000
Anwendung:: Flow Cytometry
Spezies-Reaktivität:: Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: 2-8[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Mouse
Immunogen:: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: EVSQSSSDPQLMNGVLGESAVLPLKLPAGKIANIIIWNYEWEASQVTALVINLSNPESPQIMNTDVKKRLNITQSYSLQISNLTMADTGSYTAQITTKDSEVITFKYILRVFERLGNLETTNYTLLLENGTCQIHLACVLKNQSQTVSVEWQATGNISLGGPNVTIFWDPRNSGDQTYVCRAKNAVSNLSVSVSTQSLCKGVLTN
Uniprot:: Q9ET39
Synonyme:: activating NK receptor;CD352;KA;KAL;KAL1;KAL1b;KALI;KALIb;Ly10;Ly108;lymphocyte antigen 108;natural killer-, T- and B-cell antigen;NK-T-B-antigen;NTB;NTB-A;NTBA;NTBA receptor;SF200;SF2000;SLAM family member 6
Weitere Details:: SLAMF6 (CD352/NTB-A) is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family of immunoregulatory receptors. Like other members of the SLAM receptor family, SLAMF6 possesses an extracellular region containing immunoglobulin (Ig)-like domains and an intracellular domain harboring conserved tyrosine-based signaling motifs. Upon phosphorylation, these motifs recruit the SAP (SLAM-associated protein) and EAT-2 adaptor signaling molecules. SLAMF6 is expressed on the surface of multiple immune cell lineages, including B cells, T cells, and natural killer (NK) cells. Its activation is triggered by homophilic interactions mediated through its extracellular domain. Functional studies demonstrate that SLAMF6 engagement in T cells promotes cellular activation and cytokine production. Similarly, ligand-induced homotypic binding of SLAMF6 in NK cells initiates signaling cascades that enhance proliferation, cytotoxic activity, and cytokine secretion.

Versandbedingungen:: Blue Ice