[KD Validated] ATF1 Rabbit monoclonal antibody

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SKU:: A27742
Zusätzliche Namen:: EWS-ATF1|FUS/ATF-1|TREB36
Anwendung:: ELISA, WB, IHC-P, IF, ICC
Molekulargewicht:: 35-40kDa
Spezies-Reaktivität:: Human
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Immunogen:: Recombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human ATF1 (NP_005162.1).
Formulierung:: Unmodified
Sequenz:: MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVS
Uniprot:: P18846
Synonyme:: Activating transcription factor 1;cAMP-dependent transcription factor ATF-1;cyclic AMP-dependent transcription factor ATF-1;EWS-ATF1;FUS/ATF-1;Protein TREB36;TREB36
Weitere Details:: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Versandbedingungen:: Blue Ice