[KD Validated] SREBF1 Rabbit monoclonal antibody

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SKU:: A26708
Zusätzliche Namen:: ADD1|bHLHd1|SREBP1
Anwendung:: ELISA, WB, IHC-P
Molekulargewicht:: 68 kDa/125 kDa
Spezies-Reaktivität:: Mouse
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Abclonal
Host:: Rabbit
Reaktivitäten:: Human
Immunogen:: Synthetic peptide. This information is considered to be commercially sensitive.
Formulierung:: Unmodified
Sequenz:: MDELAFGEAALEQTLAEMCELDTAVLNDIEDMLQLINNQDSDFPGLFDAPYAGGETGDTGPSSPGANSPESFSSASLASSLEAFLGGPKVTPAPLSPPPS
Uniprot:: Q9WTN3
Synonyme:: ADD-;ADD1;adipocyte determination- and differentiation-dependent factor 1;bHLHd;bHLHd1;class D basic helix-loop-helix protein 1;HMD;IFAP2;SRE;SREB;SREBP;SREBP1;sterol regulatory element-binding protein 1;Sterol regulatory element-binding transcription factor 1
Weitere Details:: This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. Alternatively spliced transcript variants have been characterized for this gene.

Versandbedingungen:: Blue Ice